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A number of natural gums and mucilages have been investigated for inclusion in pharmaceutical formulations for a variety of reasons. The search for new excipients continues to be an active topic in dosage form design and drug delivery research. The aim of this review article is to give an overview of the chemical nature of natural gums and mucilages and to discuss their applications in the formulation of pharmaceutical dosage forms.

Special emphasis will be placed on the use of gums and mucilages in novel drug delivery systems, such as modified release dosage forms and delivery systems that target specific sites of delivery. There has been increased interest in novel drug delivery systems to be administered via mucosal routes as an alternative to the currently used traditional routes such as parenteral injections and oral routes of administration.

This is due to the several advantages they offer including avoiding first pass metabolism in the liver for oral administration and local activity which avoids the need for high systemic doses.


To achieve the foregoing objectives, bioadhesive vehicles are required that ensure prolonged residence time to achieve systemic bioavailability via substantial drug absorption or significant drug concentration for local action. The drug delivery system is also required to be non-deleterious to the site of application and be well tolerated by vulnerable groups such as paediatric and geriatric patients.

These essential characteristics are mainly satisfied by naturally occurring polymers, including polysaccharide based polymers which have the advantage of biocompatibility, biodegradability and therefore safety. This review discusses various bioadhesive polymers of polysaccharide origin formulated into a variety of dosage forms for drug delivery via the body's mucosal moist surfaces including ocular, oral buccal and sublingual , nasal, gastrointestinal and vaginal mucosa, as well as moist wound sites. Cancer disease is one of the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases and around 8 million cancer-related deaths yearly.

Estimates expect to increase these figures over the next few years. Therefore, it is very important to develop more effective and targeted therapies.

Polysaccharides are widely used for biomedical and pharmaceutical applications due to their interesting properties, and can be utilised in the production of nanovehicles for drug delivery, since they frequently extend the half-life and improve the stability of chemotherapeutic agents in bloodstream allowing them to reach the tumour tissue. Moreover, polysaccharide-based nanovehicles are generally expected to increase the therapeutic benefit by reducing the undesired side effects and promoting a more efficient cellular uptake.

Here, we highlight the application of various polysaccharides as nanovehicles in cancer therapy, focusing mainly on in vivo applications and describing the main advantages of each designed system in a critical way. The use of different polysaccharides interacting with metal nanoparticles to develop new nanovehicles for cancer therapy will also be discussed.

Mano Polysaccharides belong to a special class of biopolymers that has been used in different areas of research and technology for some years now. They present distinctive features attractive for the biomedical field.

Among others, as extracted from natural sources, these materials are usually biocompatible and possess a significant ability to absorb water. Moreover, they can be conveniently modified by chemical means so as to display improved biological and physicochemical properties. The last but not the least, they are abundant in the natural Extracellular Matrix ECM and have a tremendous affinity for different endogenous macromolecules.

This review will explore the current status of nano-scale drug delivery devices based on polysaccharides that could be used in tissue engineering and regenerative medicine TERM. Aiming to contextualize the topics here discussed, especially for non-experts in the field, section 1 Introduction will present a brief overview of TERM and the principal polysaccharides herein employed. In order to get a broader perspective on both issues, this section will include a brief description of non-nanometric systems with relevant characteristics for TERM, such as injectable microparticles and macroscopic hydrogels, just to cite a few.

Section 2 will illustrate the contributions of nanotechnology to the development of TERM, in particular to the development of biomimetic systems capable of replicating the natural, endogenous ECMs. Finally, section 7 will provide an outlook on future perspectives in the field. Overall, the review is intended to constitute a critical source of information relative to the current status of polysaccharide- based biomaterials for TERM, in particular those at the nanometric scale.

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Obtaining successful ocular formulations able to support an efficient drug concentration at the target tissue for an appropriate period of time is an interesting challenge for modern pharmaceutical technology. In this sense, nanotechnology is one of the available strategies to obtain a drug carrier system that allows access to different compartments of the eye in order to deliver drugs to the desired site. Biodegradable polymers such as polysaccharides are promising biomaterials for the production of biocompatible and biodegradable nanocarriers NCs.

Different types of polysaccharide NCs are capable of improving the transport of drugs after ocular application and they can be either polysaccharide-matrix carriers or polysaccharide-coated carriers, depending on whether polysaccharide is used as a matrix or as a coating, respectively. This review focuses on recent advances achieved by polysaccharide-based NCs for the treatment of ocular disorders. Our customer care will send you specific instructions on how to ship the return package s to the retailer s.

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Natural Polysaccharides in Drug Delivery and Biomedical Applications

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Polysaccharides in Medicinal and Pharmaceutical Applications | Chemtec Publishing

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