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Clinical trials of Cisplatin Analogues. Biochemical Mechanism of Action of Platinum Complexes. The Requirement for Neutrality. Complexes of Pt IV. Nature of the Leaving Group. Bisplatinum Complexes Containing Bridging Dicarboxylates. Sulfoxides as Leaving groups. Nature of the Nonleaving Group.


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Stereospecific Effects in Amine Complexes. Ternary Complexes. Amines as Carrier Ligands. Quantitative Structure-Activity Relationships. Chemistry of Platinum-Amine Complexes.

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Structural Aspects of Metal-Nucleobase Binding. Binding in Solution. Basicity and pH. Steric Effects Including Hydrogen Bonding. Base Stacking and Chelation. Binding of Platinum Complexes in Solution. Reactivity of Platinum Metal-Base Complexes.

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Effect of Metallation on Acidity of Noncoordinated Atoms. The Platinum-N7, O6 Chelate. Effect of Metallation on C-H Exchange. Susceptibility to Oxidation of Metal-Base Complexes. Reactivity of Nucleoside and Nucleotide Linkages. Reactivity of Metal-Base Complexes toward Nucleophiles. Linkage Isomerization. Rotation around Metal-Purine Bonds. Solid State Structural Studies. Structural Studies on Di- and Oligonucleotide Complexes. Studies on Dinucleotide Complexes.

Studies on Trinucleotides. Studies on Oligonucleotides. Structural Studies on Oligonucleotides. The Platinum-Pyrimidine Blues. Properties of the Platinum-Pyrimidine Blues. Platinum Blues not Derived from Pyrimidines. X-Ray Structure of Platinum-Pyrimidine and? Formation of Platinum-Pyrimidine and?

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Monomeric Complexes. Dimeric Complexes. Complexes of Pt III. Studies of Crystalline Blues. Antitumour Activity of Metal Complexes.

Platinum Group Metal Complexes. Palladium Complexes. Rhodium Complexes. Studies on Rhodium Carboxylates. Ruthenium Complexes. Studies on Ruthenium-Amine Complexes. Copper Complexes. Bis Thiosemicarbazone Complexes. Thiosemicarbazone Complexes. Nitrogen Chelates. Copper Salicylates. Silver and Gold. Organometallic Complexes. Metal-Mediated Antibiotic Action. Discovery and Pharmacology of Bleomycin.

Structure of Bleomycin and Analogues. Metals Metal Complexes and Radiation. Metal Complexes in Arthritis. Douple effects electron enzyme guanine helix hydrogen bonding inhibition Inorg interaction intercalation interest isomers L. Marzilli labile leaving group ligand Lippert M. Hacker mechanism of action mercury Metal Chemotherapeutic Agents metal complexes Metal Ions molecules nephrotoxicity nitroimidazoles nucleotides observed Oncol oxidation oxygen Pharmacol phenanthroline platinated platinum platinum complexes Platinum Coordination potential properties Pt II purine pyrimidine radiation radical radiosensitizing reaction reactivity redox relevant rhodium ruthenium S.

Lippard salts sensitization sequence species strand structure studies summarized superoxide target thiol tion toxicity trans-isomer tumour uptake vitro vivo.